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doi: 10.1093/ajcn/64.5.772

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542 , 543 , 544 Since adaptogens downregulate AC and upregulate PDE that decreases cAMP level in brain cells (Figure 3), it was hypothesized that beneficial effects of adaptogens on stress‐induced and aging‐related weakening of cognitive functions in some extend is associated with their effect on cAMP–HCN mediated signaling pathway, 23 which is increasing in stress